Gushyira mu bikorwa ibintu birindwi birwanya antithrombotic
Hariho ubwoko bubiri bwa poroteyine zifite ingaruka za antithrombotique muburozi bwinzoka, imwe irashoboye Enzyme ifitanye isano na enzyme ya fibrinolytique yitwa fibrinolytic enzyme (plasmine ， FLE) addition Usibye kwangiza fibrin na fibrinogen, Nta gukora plasminogene mumubiri wumuntu, oya hydrolysis yibindi bintu bya coagulation Na platelet membrane, hamwe n'ingaruka zigaragara za antithrombotic.Ibindi ni muguhagarika Prothrombin imyiteguro irakorwa kugirango itinde inzira ya coagulation, kandi ntigikorwa cya enzyme.
Ubu bwoko bwa enzyme bwakozwe bwa mbere na Atoda et al Kandi Muganire kuburyo bwa anticoagulation ya proteine anticoagulant, Byemejwe ko ingaruka ziterwa na coagulation IX cyangwa coagulation X X kuri calcium ion Gukora 1: 1 kugirango byongere igihe cyo guterana;Nyuma, Lu n'abandi.kuva muri Agkistrodon acutus mu majyepfo ya Anhui Ikintu cya anticoagulant ACFI cyitaruye ubumara bwinzoka.Liu Qing Liang n'abandi.yasanze ACFI irimo ioni ya calcium, Hemejwe kandi ko ibikorwa byayo birwanya anticagulant n'imiterere yabyo byari bifitanye isano na calcium ion.Nyuma, Xu Xiaolong nabandi batandukanije ubumara bwa Agkistrodon acutus na Agkistrodon acutus hakoreshejwe uburyo bunoze bwo gutandukana ACFI I The ubushakashatsi bwo gushyira mu bikorwa uburyo bwasanze busa na AC FI kandi buri mu cyiciro cya kabiri.Zhai Ning n'abandi.yitandukanije na anticoagulant ibintu biva mu bumara bwa Agkistrodon acutus, kandi ubushakashatsi bwakozwe ku miterere y’imibiri n’imiti, kandi byagaragaye ko nta gikorwa cya fibrinolytike kandi nta gikorwa cya fosifolipase A 2 nigikorwa cyo kuva amaraso.Qian Xiaojiang nabandi batandukanije ubumara bwa Agkistrodon acutus na Hunan Ikintu gikora fibrinolytike cyarahawe akato kandi cyemezwa nikizamini cya trombolytike muri vitro Ifite ingaruka zigaragara za trombolique.Lei Danqing yatandukanijwe nuburyo butatu bwa chromatografiya Kandi ibikorwa bya plasmin byateye imbere cyane.Kuberako ibice bya plasmin birimo Amaraso biragoye gutandukana, kandi agaciro kayo kavuriro ntigaragara.Li Zhaoyan et al Binyuze mubikorwa byo kubona enzyme ya fibrinolytike idafite amaraso yamashanyarazi Inkunga yatanzwe na.Zhou Xianli] ituma reanalisation yimiyoboro yamaraso gahoro gahoro, Kongera kwihanganira imiyoboro yamaraso mugace ka ischemic, kandi ukarokoka guturika kw'imitsi iterwa no guterwa amaraso Cleavage igira ingaruka nziza mugihe cyambere cya trombose, kandi byombi bikoreshwa hamwe, Birashobora kugabanya ibipimo kandi bigera kuri anticoagulant na trombolytique.Gukoresha imiti irindwi ya Antithrombotic Hariho ubwoko bubiri bwa poroteyine zifite ingaruka za antithrombotique muburozi bwinzoka, imwe ishoboye Enzyme ifitanye isano na enzyme ya fibrinolytique yitwa enzyme ya fibrinolytike (plasmine ， FLE)。 Usibye gutesha agaciro fibrin na fibrinogen, Nta gukora kwa plasminogene mumubiri wumuntu, nta hydrolysis yizindi mpamvu ziterwa na coagulation Na platelet membrane, hamwe na antithrombotic igaragara.Ibindi ni muguhagarika Prothrombin imyiteguro irakorwa kugirango itinde inzira ya coagulation, kandi ntigikorwa cya enzyme.
Ubu bwoko bwa enzyme bwakozwe bwa mbere na Atoda et al Kandi Muganire kuburyo bwa anticoagulation ya proteine anticoagulant, Byemejwe ko ingaruka ziterwa na coagulation IX cyangwa coagulation X X kuri calcium ion Gukora 1: 1 kugirango byongere igihe cyo guterana;Nyuma, Lu n'abandi.kuva muri Agkistrodon acutus mu majyepfo ya Anhui Ikintu cya anticoagulant ACFI cyitaruye ubumara bwinzoka.Liu Qing Liang n'abandi.yasanze ACF irimo calcium ion Byemejwe kandi ko ibikorwa byayo birwanya anticagulant n'imiterere yabyo byari bifitanye isano na calcium ion.Nyuma, Xu Xiaolong nabandi batandukanije uburozi bwa Agkistrodon acutus na Agkistrodon acutus hakoreshejwe uburyo bunoze bwo gutandukana Ikindi kintu kirwanya anticagulant ACFI I Ubushakashatsi bwashyizwe mubikorwa bwerekanye ko busa na AC FI kandi buri mubyiciro bya kabiri.Zhai Ning n'abandi.yatandukanije ikintu gishya cya anticoagulant ku burozi bwa Agkistrodon acutus, kandi ubushakashatsi bw’imiterere n’umubiri n’imiti byaragaragaye, kandi byagaragaye ko nta gikorwa cya fibrinolytike kandi nta gikorwa cya fosifolipase A 2 nigikorwa cyo kuva amaraso.Qian Xiaojiang nabandi batandukanije ubumara bwa Agkistrodon acutus na Hunan Ikintu gikora fibrinolytike cyarahawe akato kandi cyemezwa nikizamini cya trombolytike muri vitro Ifite ingaruka zigaragara za trombolique.Lei Danqing yatandukanijwe nuburyo butatu bwa chromatografiya Kandi ibikorwa bya plasmin byateye imbere cyane.Kuberako ibice bya plasmin birimo Amaraso biragoye gutandukana, kandi agaciro kayo kavuriro ntigaragara.Li Zhaoyan et al Binyuze mubikorwa byo kubona enzyme ya fibrinolytike idafite amaraso yamashanyarazi Inkunga yatanzwe na.Zhou Xianli] ituma reanalisation yimiyoboro yamaraso gahoro gahoro, Kongera kwihanganira imiyoboro yamaraso mugace ka ischemic, kandi ukarokoka guturika kwamaraso guterwa no guterwa amaraso Cleavage igira ingaruka nziza mugihe cyambere cya trombose, kandi byombi bikoreshwa hamwe
Irashobora kugabanya ibipimo no kugera kuri anticoagulant na trombolytique.
Igihe cyo kohereza: Ukwakira-19-2022