Ingaruka Zibuza Igice cya I cya Agkistrodon halys Venom kubikorwa byimuka byimitsi ya Endoteliyale.

Kureba ingaruka z'igice cyo kurwanya ibibyimba I by'uburozi bwa Agkistrodon acutus (AAVC-1) ku gikorwa cyo kwimuka kw'imitsi yo mu nda ya endoteliyale y'umuntu (HUVECs), no gushakisha uburyo bushoboka bwa AAVC - Ⅰ kubuza angiogenez.Uburyo: HUVECs yarezwe muri vitro hamwe na AAVC - Ⅰ (0, 20, 40, 80 μ G / ml) ingirabuzimafatizo zavuwe zashyizwemo amasaha 24.Ikizamini cya Scratch hamwe na chimotactique chambre byakoreshejwe kugirango harebwe ingaruka za AAVC - Ⅰ kubikorwa byimuka byimuka ya endothelia;RT-PCR na blot yo muburengerazuba byakoreshejwe kugirango hamenyekane impinduka za mRNA na proteyine za P-selinine hamwe ningingo zifatika zifatika (ICAM-1) mbere na nyuma yo kuvura ibiyobyabwenge.Ibisubizo: Ugereranije na HU VECs mumatsinda isanzwe, ubushobozi bwo kwimuka kwingirabuzimafatizo muri AAVC - groups amatsinda yibandaho yagabanutse kuburyo butandukanye, kandi imvugo ya P-selectin na ICAM-1 mRNA yagabanutse cyane.Umwanzuro: AAVC - Ⅰ irashobora guhagarika ibikorwa byo kwimuka kwingirabuzimafatizo ya endoteliyale mukugabanya urwego rwa mRNA na proteyine za P-selinine na ICAM-1