Ikigo cya inzoka Venom na Snakebite, Ishuri Rikuru ryubuvuzi rya Anhui
Ikigo cy'ubushakashatsi mu mujyi wa Wuhu, Intara ya Anhui
Ubushakashatsi ku burozi bw’inzoka n’igikomere cy’inzoka mu Ishuri Rikuru ry’Ubuvuzi rya Anhui ryatangiye hagati mu myaka ya za 70, kandi yari umwe mu bagize itsinda ry’abafatanyabikorwa mu kuvura inzoka mu Ntara ya Anhui icyo gihe.Nimwe mubigo byambere byakoze ubushakashatsi bwibanze kandi bukoreshwa muburozi bwinzoka mubushinwa.
Izina ry'igishinwa
Ikigo cya inzoka Venom na Snakebite, Ishuri Rikuru ryubuvuzi rya Anhui
ikibanza
Intara ya Anhui
Ubwoko
impamyabumenyi
ikintu
Uburozi bwinzoka ninzoka
Ibyagezweho mu bushakashatsi bw'Ikigo
Intangiriro y'Ikigo
Ubushakashatsi ku burozi bw’inzoka n’igikomere cy’inzoka mu Ishuri Rikuru ry’Ubuvuzi rya Anhui ryatangiye hagati mu myaka ya za 70, kandi yari umwe mu bagize itsinda ry’abafatanyabikorwa mu kuvura inzoka mu Ntara ya Anhui icyo gihe.Mu 1984, iyobowe na Porofeseri Wen Shangwu, umuyobozi w’ishami ry’inyigisho n’ubushakashatsi bw’abanyeshuri barwaye mbere, hashyizweho ibiro by’ubushakashatsi bw’inzoka n’ubushakashatsi bw’inzoka, kikaba ari kimwe mu bigo bya mbere byakoze ubushakashatsi bw’ibanze kandi bukoreshwa. ku burozi bw'inzoka mu Bushinwa.Mu 2007, Ibiro by’ubushakashatsi by’inzoka n’inzoka byahinduwe ikigo cy’ubushakashatsi bw’inzoka y’ubushakashatsi bw’ishuri rikuru ry’ubuvuzi rya Anhui, naho umuyobozi usanzwe ni Porofeseri Zhang Genbao.Mu myaka 30 ishize, ibyingenzi kandi byashyizwe mubikorwa ubushakashatsi bwakozwe nuburozi bwinzoka zifite ubumara mu majyepfo ya Anhui bwagize uruhare runini mu gukumira no kugenzura ibikomere by’inzoka no gukoresha umutungo w’inzoka mu Bushinwa;Inzoka nyamukuru zifite ubumara mu majyepfo ya Anhui ni Agkistrodon acutus (Agkistrodon acutus), Agkistrodon acutus, Cobra, Green Bamboo Leaf Snake, Chromium Iron Head na Bungarus multicinctus, cyane cyane Agutistrodon acutus, igira ingaruka zikomeye ku buzima no ku mibereho yabantu bo mu misozi.Ubushakashatsi bwerekanye ko izo nzoka zifite ubumara zitanga cyane cyane uburozi bwamaraso hamwe na neurotoxine, zishobora gutuma abarwayi barwara indwara ya coagulation ikwirakwizwa (DIC) no kuva amaraso ya kabiri, guhungabana, kunanirwa kwingingo nyinshi nizindi ngaruka zikomeye;Binyuze mu bushakashatsi butunganijwe ku maraso y’uburozi bw’ubumara bwa Agkistrodon acutus (Agkistrodon acutus) mu majyepfo ya Anhui, byagaragaye ko DIC ifitanye isano n’inzoka ari kimwe mu bimenyetso byaranze uburozi hakiri kare, kandi itandukanye na DIC yagaragaye mu muco gakondo ibitekerezo.Kubwibyo rero, igitekerezo cya syndrome ya “DIC like” ku barwayi barumwe na Agkistrodon acutus cyatanzwe bwa mbere mu Bushinwa (1988), Byemejwe kandi ko trombine nka enzyme (TLE) na enzyme ya fibrinolytike (FE) ikubiye mu burozi bwa Agkistrodon acutus yari impamvu nyamukuru zitera iyi "DIC nka" (1992).Ibi bifite akamaro kanini mugusobanura ibiranga ihinduka ryamaraso kubarwayi barwaye Agkistrodon acutus, kandi binatanga ishingiro ryamahame yo gukoresha antivnom yihariye yo kuvura iki kibazo.Mu bushakashatsi bwakozwe ku buryo bwo kuva amaraso bwatewe n'uburozi bwa Agkistrodon acutus, bwagaragaye kandi ko ubwo bumara bw'inzoka bwagize ingaruka ku bice bitatu by'ingenzi bigize sisitemu ya hemostatike (ibintu bya coagulation, platine n'inkuta z'amaraso), muri byo haemotoxine itaziguye byagize ingaruka kuri capillaries.Muri icyo gihe kandi, hamenyekanye ko kuva amaraso akomeye yatewe n'uburozi bwa Agkistrodon acutus acutus hamwe n'ingorane zo kubyimba ingingo zakomeretse kugira ngo bigabanuke byari bifitanye isano no guhagarika lymphatike yongerera ibintu bya coagulation mu muyoboro wa thoracic ndetse n'umuvuduko ukabije wa lymphatique.Ibi bintu by'ibanze kandi byashyizwe mu bikorwa by’ubushakashatsi byagize uruhare runini mu bufatanye bw’igihe kirekire n’ikigo cy’ubushakashatsi cya Qimen Snakebite mu gutegura neza gahunda yo kuvura inzoka zifite ubumara no kurinda umutekano w’abarwayi b’inzoka, kandi byageze ku mibereho ikomeye.Ibyagezweho mu bushakashatsi byatsindiye igihembo cya Siyanse n'Ikoranabuhanga mu Ntara ya Anhui, Igihembo cya Siyanse n'Iterambere mu Ntara ya Anhui (1993), na (A) ku rwego rwa Siyanse n'Ikoranabuhanga Achievement Collective Award ya Minisiteri y'Ubuzima (1991);Mu 1989, yafatanyije n’ikigo cya Wuhan cy’ibicuruzwa by’ibinyabuzima gukora antibody ya monoclonal irwanya trombine nka enzyme y’ubumara bwa Agkistrodon acutus, bwari bwo bwa mbere mu Bushinwa;Mu 1996, yafatanije gukora no guteza imbere ibicuruzwa bya trombine (YWYZZ 1996 No 118004, ipatanti CN1141951A) hamwe n’ikigo cy’ibicuruzwa n’ibinyabuzima n’ibiyobyabwenge byo mu karere ka gisirikare ka Jinan.
ibyavuye mu bushakashatsi
Mu myaka yashize, laboratoire yatandukanije kandi isukura ibintu bitandukanye bioaktique nubumara bubi bwa Agkistrodon acutus, Agkistrodon halys na Cobra mu majyepfo ya Anhui, nka enzymes za leta zirwanya hypercoagulable, abashinzwe poroteyine C (PCA).Ubushakashatsi bwakozwe bwerekanye ko ibyo bikoresho bishobora kugira ingaruka ku mikorere ya coagulation, bikagira ingaruka ku gufatira kwa platine, kwegeranya no kurinda imikorere y’uturemangingo twa endoteliyale, kandi bifite imikorere myiza n’uburozi buke bwa anticoagulation n'ingaruka za trombolytike, Ibi bifite akamaro kanini mu gukumira no kuvura y'indwara ya trombotique no kunoza hypercoagulability y'amaraso;Muri icyo gihe, byagaragaye kandi ko PCA iva mu bumara bwinzoka igira ingaruka zihariye zo kwica selile K562 no guhagarika metastasis ya selile kanseri.Ibyifuzo byayo byo kuvura biragutse cyane.Ibiro by’ubushakashatsi byagiye bikurikirana kandi birangiza imishinga myinshi y’ubushakashatsi, nka “Mechanism of DIC yatewe n'uburozi bwa Agkistrodon acutus”, “Ubushakashatsi ku buryo bwo kuva amaraso buterwa n'uburozi bwa Agkistrodon acutus mu nyamaswa”, “Gusuzuma inzoka no gusuzuma itandukaniro ryayo umuryango w'inzoka hakoreshejwe uburyo bwo gushyiramo enzyme ”, uterwa inkunga na Fondation National Science Science, Minisiteri y'Ubuzima, Ishami ry'Ubuzima n'ishami ry'uburezi mu Ntara ya Anhui;Kugeza ubu, imishinga irimo gutezwa imbere irimo: “Ubushakashatsi kuri Poroteyine ya Hemorrhagic Anticoagulant ya Agkistrodon acutus”, “Ubushakashatsi ku mikorere ya molekulike y’ingaruka za PCA ziva muri Agkistrodon halys Pallas Venom ku mikorere ya Vascular Endothelial”, “Ubushakashatsi kuri Biologiya ya Molecular. PCA yo muri Agkistrodon acutus Venom irwanya Utugingo ngengabuzima twa Tumor ”, no Gutandukanya no Kweza Ibice bya Analgesic Nerv biva muri Cobra Venom.
Ikigo cy’ubushakashatsi bw’ubumara bwinzoka yo mu majyepfo y’ubuvuzi bwa Anhui gifite imiterere myiza, ibikoresho byuzuye byubushakashatsi, imiterere yitsinda ryubushakashatsi, hamwe niterambere rihoraho muburyo bwubushakashatsi nuburyo bwa tekiniki.Biteganijwe ko hari byinshi bizagerwaho mubushakashatsi bwa siyanse, guhugura abakozi, nibindi. Uburozi bwinzoka mu majyepfo ya Anhui burakize cyane kandi bufite agaciro.Farumasi yubumara bwinzoka nibiyobyabwenge bifite uburenganzira bwumutungo wubwenge mubushinwa.Ubushakashatsi bwakozwe bushingiye ku gukoresha no gukoresha ubumara bwinzoka nibiyigize bifite akamaro kanini mugutezimbere umutungo w’ubumara bwinzoka mu majyepfo ya Anhui no kubuvura.
Igihe cyo kohereza: Ugushyingo-11-2022