Pharmacokinetics ya trombine kuva Agkistrodon acutus mu mbeba

[Abstract] Haemocoagulase Acutus (Halase), thermostatike nshya mu iterambere rya halase, ni trombobine ikora cyane nka enzyme (TLE) ikomoka ku bumara bwinzoka ya Agkistrodon acutus Kwiga farumasi ya Halase, uburyo bwa 125Ⅰ bwanditse kuri radioisotope hamwe na radioassay hamwe na TCA precip-itate yakoreshwaga mu mbeba.Ibisubizo byerekanaga ko indangagaciro za AUC zahujwe neza na dosiye muburyo bwombi bwakoreshejwe, naho coefficient zifitanye isano ni 0,999 8 na 0.999 0;ibiyobyabwenge byangiza umwijima, impyiko n'umutima byageze ku rwego rwo hejuru nyuma yiminota 5 yubuyobozi mugihe abandi benshi cyangwa gans babigezeho muminota 30, hanyuma bigabanuka buhoro buhoro;muri buri mwanya, ibiyobyabwenge byibasiye umwijima byari hejuru cyane ugereranije nibindi bice;Halase yasohotse rwose kandi cyane cyane mu nkari.% Thrombine yo muri Agkistrodon acutus ni ubwoko bwa trombine bwitaruye kandi bwezwa muburozi bwa Agkistrodon acutus.Nubwoko bushya bwimiti ya hemostatike yatunganijwe nitsinda ryacu Pharmacokinetics ya trombine ivuye muri Agkistrodon acutus yimbeba yakozwe nubushakashatsi bwa 125 I bwanditseho radioisotope hamwe nubushyuhe bwa acide trichloroacetic hamwe no gutahura radio.Ibisubizo byagaragaje ko indangagaciro za AUC zapimwe nuburyo bubiri zahujwe neza nigipimo, naho coefficient zifitanye isano ni 0.9998 na 0.9990;Ibiyobyabwenge biri mu mwijima, mu gihimba no mu mutima nibyo byabaye min min 5 nyuma yubuyobozi, mugihe ko mubindi bice byinshi byari min 30 min nyuma yubuyobozi, hanyuma bikagabanuka buhoro buhoro;Kuri buri mwanya, ibiyobyabwenge biri mubice byumwijima byari hejuru cyane ugereranije nibindi bice;Byongeye kandi, gusohora trombine ya Agkistrodon acutus iruzuye, cyane cyane ninkari