Inzoka Zinzoka Ziva muri Agkistrodon (Inzoka yintambwe eshanu) igomba kuvurwa hamwe na serumu ya Antihematique

Inzoka Zinzoka Ziva muri Agkistrodon (Inzoka yintambwe eshanu) Zigomba Kuvurwa na Serumu Antihematique

Ibisobanuro bigufi:

Ibigeragezo bibiri byamavuriro byakozwe, igeragezwa ryateguwe na platbo ryateganijwe kandi ryagenzuwe neza.Ibikomere byose byavaga amaraso binyuze mu gutema urukuta rw'inda mu kubaga inda.Ibipimo nyamukuru byo kuvura byari ugutakaza amaraso, igihe cya hemostasis no gutakaza amaraso kuri buri gice.Ikibanza cyemewe mubigeragezo byamavuriro mubibazo 180 byabantu: igipimo cyingingo zingana zingana na placebo, 2 u na 3 u matsinda atatu, mbere yo gutangira iminota 15-20 inshuro imwe imwe yo gutera imitsi, ibisubizo byerekana iyi dosiye ebyiri mugihe cyo kuva amaraso, mugihe cyo kuva amaraso na gutakaza amaraso kumurongo wigice cyarutaga umwanya wa placebo, ariko nta sano yo gusubiza-guhuza amatsinda abiri.Mu igeragezwa ryiza ryakozwe, mu itsinda ry’ubushakashatsi hari abarwayi 324 n’abarwayi 108 mu itsinda rishinzwe kugenzura, kandi ikinini kimwe cya 2U cyatanzwe mu itsinda ry’ubushakashatsi iminota 15-20 mbere yo kubagwa hakoreshejwe inshinge imwe.Nta ngaruka mbi zagaragaye mu bizamini byavuzwe haruguru.

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Ibicuruzwa birambuye

Ibicuruzwa

Ubushakashatsi bwerekanye ko inzoka zifite ubumara zitanga cyane cyane uburozi butembera mu maraso na neurotoxine, zishobora gutera gukwirakwiza imitsi y'amaraso (DIC) no kuva amaraso, guhungabana no kunanirwa kw'ingingo nyinshi.Hashingiwe ku bushakashatsi bwa sisitemu y’uburozi bw’amaraso y’ubumara bw’inzoka mu majyepfo ya Anhui, wasangaga DIC ari kimwe mu byaranze abarwayi bakomeretse inzoka bafite uburozi hakiri kare, ibyo bikaba bitandukanye n’imvugo gakondo ya DIC.Kubwibyo, igitekerezo cya "DIC nka" syndrome mu barwayi baruma inzoka cyatanzwe bwa mbere mu Bushinwa (1988).Byagaragaye ko TLE na FE arizo mpamvu nyamukuru zateye iyi "DIC nka" (1992).Ibi bifite akamaro kanini mugusobanura ibiranga ihinduka ryamaraso kubarwayi bafite ubumara bwinzoka zintambwe eshanu, kandi binatanga ishingiro ryamahame yo gukoresha antivenom yihariye kugirango ivure iki kibazo.

Mu bushakashatsi bwakozwe ku buryo bwo kuva amaraso buterwa n'uburozi bw'intambwe eshanu, byagaragaye kandi ko ubwo bumara bw'inzoka bugira ingaruka ku bice bitatu bigize sisitemu yo mu mubiri (ibintu bya coagulation, platine n'inkuta z'amaraso), muri byo hakaba harimo kuva amaraso. uburozi bugira ingaruka itaziguye ya capillaries.Muri icyo gihe kandi, byagaragaye ko kuva amaraso menshi no kubyimba ingingo zakomeretse bitari byoroshye kubikemura, bikaba byari bifitanye isano no guhagarika itangwa ry’amaraso ya thoracic duct lymphatic coagulation hamwe n'umuvuduko muke w'amazi atemba.Mu bufatanye burambye n’ikigo cya qimen Snakebite, ibisubizo by’ibanze kandi byashyizwe mu bikorwa by’ubushakashatsi byagize uruhare runini mu gutegura neza gahunda yo kuvura inzoka no kurinda umutekano w’abarwayi b’inzoka, kandi byageze ku mibereho ikomeye.Ibyagezweho mu bushakashatsi byatsindiye igihembo cy’ubumenyi n’ikoranabuhanga mu Ntara ya Anhui, igihembo cy’ubumenyi n’ikoranabuhanga mu Ntara ya Anhui (1993), Minisiteri y’Ubuzima (A) Icyiciro cya siyansi n’ikoranabuhanga Achievement Group Award (1991);Mu 1989, isosiyete yafatanije n’ikigo cya Wuhan Institute of Biological Products mu gukora antibody ya monoclonal kurwanya penta inzoka y’ubumara ya trombine, ikaba ari yo ntsinzi ya mbere mu Bushinwa.Mu 1996, isosiyete yafatanyije gukora no guteza imbere ibicuruzwa bya trombine hamwe n’ikigo cy’ibicuruzwa n’ibinyabuzima n’ibiyobyabwenge by’ubuyobozi bukuru bwa gisirikare bwa Jinan (Icyemezo cy’ibiyobyabwenge cya Yuwei No 118004, Patent CN1141951A).